臓器保存

臓器保存とキメラ

世界的に深刻なドナー不足を解決すべく、異種動物の肝構築をscaffoldとして肝細胞をhumanのものに置換する“キメラ肝臓”の開発や、種々の肝障害抑制や肝再生促進効果を有する間葉系幹細胞移植の臨床応用、さらには、新たなる肝灌流保存法の開発とNOやCO等Gas Biologyの臓器保存への応用(Graft “Post-conditioning”)等研究内容は多岐に渡ります。

まだ新しい研究室ですので 実績の蓄積はこれからですが、多くの大学院生達と共に、未来の移植医療を開拓すべく日々研究に邁進しています。

To solve “World health crisis” of donor shortage, we have been executing various basic/ clinical researches, also in the transplant fields: Development of “Chimeric liver” using xenogenic hepatic architecture as “scaffold” with replacement of human hepatocytes; Mesenchymal stem cell transplantation with liver transplantation, anticipating various protective and regenerative effects to small/damaged liver grafts; Development of novel strategy/algorithm for intensive portal venous pressure control; Development of a novel perfusion preservation of liver grafts, heading for the new concept of graft “Post-conditioning”.

連絡先:
秦 浩一郎:khata@kuhp.kyoto-u.ac.jp

業績

1、Hori T, Kaido T, Oike F, Ogura Y, Ogawa K, Yonekawa Y, Hata K, Kawaguchi Y, Ueda M, Mori A, Segawa H, Yurugi K, Takada Y, Egawa H, Yoshizawa A, Kato T, Saito K, Wang L, Torii M, Chen F, Baine AM, Gardner LB, Uemoto S. Thrombotic microangiopathy-like disorder after living-donor liver transplantation: A single-center experience in Japan. World J Gastroenterol. 2011 Apr 14;17(14):1848-57. PubMed PMID: 21528059; PubMed Central PMCID: PMC3080720.

2、Kaido T, Mori A, Oike F, Mizumoto M, Ogura Y, Hata K, Yoshizawa A, Iida T, Uemoto S. Impact of pretransplant nutritional status in patients undergoing liver transplantation. Hepatogastroenterology. 2010 Nov-Dec;57(104):1489-92. PubMed PMID: 21443108.

3、Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, Iida T, Uemoto S. Recurrence of Hepatocellular Carcinoma after Living Donor Liver Transplantation: What is the Current Optimal Approach to Prevent Recurrence? World J Surg. 2011 Jun;35(6):1355-9. PubMed PMID: 21424873.

4、Hata T, Iwasaki J, Hishikawa S, Fujimoto Y, Uemoto S, Kobayashi E. Development of a portocaval shunt using a small intestinal segment in rats. Microsurgery. 2010 May;30(4):302-6. PubMed PMID: 20309853.

5、Iwasaki J, Hata T, Hishikawa S, Fujimoto Y, Uemoto S, Murakami T, Kobayashi E. Use of rat segmental intestine for fetal pancreatic transplantation. Microsurgery. 2010 May;30(4):296-301. PubMed PMID: 20309851.

6、Iida T, Kaido T, Yagi S, Yoshizawa A, Hata K, Mizumoto M, Mori A, Ogura Y, Oike F, Uemoto S. Posttransplant bacteremia in adult living donor liver transplant recipients. Liver Transpl. 2010 Dec;16(12):1379-85. doi: 10.1002/lt.22165. PubMed PMID: 21117247.

7、Hori T, Oike F, Ogura Y, Ogawa K, Hata K, Yonekawa Y, Ueda M, Sakamoto S, Kasahara M, Egawa H, Takada Y, Kaido T, Hatano E, Nguyen JH, Chen F, Baine AM, Uemoto S. Liver transplantation for congenital biliary dilatation: a single-center experience. Dig Surg. 2010;27(6):492-501. Epub 2010 Nov 10. PubMed PMID: 21063126.

8、Hori T, Nguyen JH, Zhao X, Ogura Y, Hata T, Yagi S, Chen F, Baine AM, Ohashi N, Eckman CB, Herdt AR, Egawa H, Takada Y, Oike F, Sakamoto S, Kasahara M, Ogawa K, Hata K, Iida T, Yonekawa Y, Sibulesky L, Kuribayashi K, Kato T, Saito K, Wang L, Torii M, Sahara N, Kamo N, Sahara T, Yasutomi M, Uemoto S. Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide. World J Gastroenterol. 2010 Jul 7;16(25):3120-32. PubMed PMID: 20593497; PubMed Central PMCID: PMC2896749.

9、Iida T, Kaido T, Mori A, Nagata H, Hata K, Koizumi M, Mizumoto M, Ogura Y, Oike F, Uemoto S. The rare insertion of b4 with trifurcated portal vein in live donor. Transplantation. 2010 May 15;89(9):1163-4. PubMed PMID: 20440197.

10、Hori T, Wagata T, Takemoto K, Shigeta T, Takuwa H, Hata K, Uemoto S, Yokoo N. Spontaneous necrosis of solid gallbladder adenocarcinoma accompanied with pancreaticobiliary maljunction. World J Gastroenterol. 2008 Oct 14;14(38):5933-7. Review. PubMed PMID: 18855999; PubMed Central PMCID: PMC2751910.

11、Wei L, Hata K, Doorschodt BM, Büttner R, Minor T, Tolba RH. Experimental small bowel preservation using Polysol: a new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution? World J Gastroenterol. 2007 Jul 21;13(27):3684-91. PubMed PMID: 17659727.

12、Hata K, Tolba RH, Wei L, Doorschodt BM, Büttner R, Yamamoto Y, Minor T. Impact of polysol, a newly developed preservation solution, on cold storage of steatotic rat livers. Liver Transpl. 2007 Jan;13(1):114-21. PubMed PMID: 17117434.

13、Hata K, Yamamoto Y, Nakajima A, Taura K, Yonezawa K, Uchinami H, Ikeda F, Yamaoka Y. Induction of heme oxygenase-1 and dilatation of hepatic sinusoids by an administration of pyrrolidine dithiocarbamate in rat livers. J Surg Res. 2003 Dec;115(2):310-7. PubMed PMID: 14697299.